Why Trazodone Doesn't Work on My Dog and What to Try

Trazodone doesn't work on my dog, and I'm not alone. Many pet owners have tried this medication to calm their anxious dogs, but it often falls short.

The reason trazodone may not work on your dog is that it's metabolized differently in canines than in humans. In fact, studies have shown that dogs have a higher concentration of the medication in their liver, which can lead to toxic levels.

For some dogs, trazodone can take up to 4 weeks to start working, but even then, it may not be effective. This is because individual tolerance and sensitivity to the medication can vary greatly from one dog to another.

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Trazodone may not work for your dog if it's not used at the right dosage. A typical starting dose is 25-50 mg per 10 pounds of body weight, but this can vary depending on the individual dog's needs.

Some dogs may not respond to trazodone because their underlying medical issue is not related to serotonin levels. For example, if your dog is experiencing pain or arthritis, trazodone may not provide relief.

It's also possible that trazodone may interact with other medications your dog is taking, reducing its effectiveness.

Additional reading: How Long Does Trazodone Take to Work in a Dog

If your vet has prescribed trazodone for your dog's anxiety, but it's not working, there are other options to explore. You can talk to your vet about switching to a different medication, such as fluoxetine or clomipramine, which are also available at your pharmacy.

In some cases, training can be an effective way to change your dog's anxiety-based behavior. This may require the help of a professional dog trainer, and it's not always easy.

There are also many products on the market that can help relieve your dog's stress, from calming shirts to pheromone sprays to calming dog crates. These products can be a good alternative to medication, and they're definitely worth considering.

Your vet may recommend trying a combination of these options, so be sure to discuss all the possibilities with them.

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Dogs generally tolerate trazodone well, but some may experience sedation and drowsiness.

If your dog is sedated or drowsy, it's essential to monitor their behavior and adjust their dosage accordingly.

Lethargy is another possible side effect, which can be concerning if your dog is normally energetic and playful.

Some dogs may also experience vomiting, colitis, or ataxia, which is a drunken gait that can be unsteady and unpredictable.

Heart arrhythmia is a serious side effect that requires immediate veterinary attention.

Increased appetite is a common side effect, but it's essential to ensure your dog's weight and overall health aren't compromised.

If your dog is experiencing increased anxiety or agitation, it's crucial to stop the medication and consult with your vet.

Here are some common side effects of trazodone in dogs: