
Cat scratch disease, also known as cat scratch fever, is a bacterial infection caused by Bartonella henselae.
According to statistics, approximately 40,000 people in the United States are infected with cat scratch disease each year.
Cat scratch disease can cause swollen lymph nodes, usually in the neck, armpits, or groin, which can be painful and tender to the touch.
In severe cases, the disease can lead to more serious complications, such as swelling of the brain or spinal cord, which can be life-threatening.
The incubation period of cat scratch disease is typically 3 to 10 days after being scratched or bitten by an infected cat.
Consider reading: What Causes Cat Scratch Disease
Incidence and Statistics
Cat scratch disease is more common than you might think, with 4.5 out of every 100,000 Americans under the age of 65 being diagnosed with it each year.
The majority of cases, 12,735 out of 13,273, are outpatient diagnoses, meaning people are seen by a doctor and sent home.
The average annual incidence of outpatient diagnoses peaked in 2005 at 5.7/100,000 population and steadily declined to a low of 4.0/100,000 population in 2013.
In contrast, inpatient admissions remained relatively stable during the study period, with a slight peak in 2008 at 0.22/100,000 population.
The West North Central region of the United States, which includes Minnesota, had a lower incidence rate of 3.3 per 100,000 residents.
The annual direct medical cost to the U.S. for treating cases of cat-scratch disease is estimated to be $9.7 million.
Fewer than 1 in 500,000 Americans need to be hospitalized as a result of cat-scratch disease, with only 538 people out of 13,273 cases requiring hospitalization.
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Disease Impact
Cat scratch disease can have a significant impact on individuals, particularly those under 21 years of age.
Most cases occur in people under 21, with a majority of cases occurring in this age group.
The disease can cause painful regional lymph nodes, which may be felt as small bumps under the skin, and a low-grade fever of about 101 F.
A significant percentage of affected patients develop a low-grade fever, which can range from mild to moderate.
Many cases of cat scratch disease are not reported because the symptoms are often mild and the disease is self-limiting.
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Disease Complications

Cat scratch disease (CSD) can be a relatively harmless condition for most people, but it's essential to be aware of the potential complications that can arise, especially for those with weakened immune systems. In fact, up to 10% of cases can lead to complications in immunocompromised patients.
For those with healthy immune systems, complications are rare. However, if you do develop swollen lymph nodes, headache, fever, and fatigue, it's a good idea to see a doctor.
Complications can affect various organ systems, including the brain, lungs, heart, bones, eyes, and liver. In severe cases, CSD can cause encephalopathy, leading to confusion and even coma.
Pneumonia is another possible complication, characterized by respiratory problems, cough, and difficulty breathing. This can be a serious condition that requires prompt medical attention.
Other potential complications include endocarditis, osteomyelitis, neuroretinitis, otic neuralgia, and hepatitis. These conditions can cause a range of symptoms, from shortness of breath and chills to abdominal pain and hearing loss.
Here's a list of some possible complications of CSD:
- Encephalopathy (confusion, coma)
- Pneumonia (respiratory problems; cough, difficulty breathing)
- Endocarditis (short of breath, chills, and fevers)
- Osteomyelitis (bone pain)
- Neuroretinitis (blindness)
- Otic neuralgia (hearing loss)
- Hepatitis (abdominal pain)
Disease Prognosis

The prognosis for cat scratch disease is quite reassuring. Symptoms resolve in about two to five months in nonimmunocompromised patients, and complications are rare.
In fact, the disease is self-limiting, meaning it will run its course without treatment. This is good news for people who contract the disease, as they can expect a relatively smooth recovery.
The bacteria responsible for the disease, Bartonella henselae, is not transmitted from person to person, so there's no risk of spreading it to others. This is a significant relief for those who contract the disease.
Immunocompromised patients may take longer to recover, but with appropriate treatment, they can still recover completely. This includes patients with weakened immune systems due to medical conditions or medications.
Here's a summary of the prognosis for cat scratch disease:
Epidemiology
Cat scratch disease is a zoonotic infection that affects people of all ages, but it's more common in children aged 5 to 9 years and older adults aged 60 to 64 years.
In the United States, the incidence of cat scratch disease has been declining over the years, from 5.1 cases per 100,000 individuals in 2005 to 4.0 cases per 100,000 by 2013.
According to a study, the total direct medical costs associated with cat scratch disease in the United States are estimated to be nearly $9.8 million annually.
Cat scratch disease can be prevented through the use of flea control measures in cats and thorough hand washing after handling cats. Reducing feline contact with young children may also help reduce the risk.
Here's a breakdown of the annual incidence of cat scratch disease in the United States over the study period:
What Causes Disease?
Cat scratch disease is a fascinating example of how a tiny bacterium can cause a big problem. Bartonella henselae, a pleomorphic (multishaped) Gram-negative bacterium, is responsible for the vast majority of CSD.
This bacterium is quite sneaky and requires special laboratory conditions to be cultured, which makes it hard to detect in patient samples. It's estimated that about 40% of all cats carry Bartonella henselae at some point in their life, and fleas play a key role in passing the bacteria to cats in a flea-cat-flea cycle.
The bacteria have also been detected in cat saliva and on cat claws, which is how they can transfer to humans through scratches or bites. It's worth noting that these bacteria were only identified as the cause of CSD in 1985, and they were initially classified as Rochalimaea henselae before being reclassified as Bartonella henselae due to genetic differences.
Here's a quick rundown of how the disease is transmitted:
- Fleas pass the bacteria to cats in a flea-cat-flea cycle.
- Cats carry the bacteria in their saliva and on their claws.
- Humans can get infected through scratches or bites from an infected cat.
Comparisons Over Time
Comparisons over time reveal interesting trends in the incidence and characteristics of patients with CSD. During the 3-year period of 2005-2007, a total of 2,881 patients were given a CSD diagnosis, with an incidence of 5.5 cases per 100,000 population per year.
The number of patients with CSD increased significantly over time, with 5,522 patients receiving a diagnosis in 2011-2013. This increase is likely due to the expanded coverage of the MarketScan database during the latter period.
Hospitalization rates for CSD patients also rose, from 3.5% in 2005-2007 to 4.2% in 2011-2013. This suggests that CSD may be becoming more severe or that treatment options are changing over time.
Interestingly, the proportion of patients under 14 years of age decreased significantly between the two periods, from approximately 14% in 2005-2007 to around 10% in 2011-2013. This could indicate that CSD is becoming less common in younger populations.
The seasonal distribution of CSD diagnoses also shifted over time, with fewer patients receiving a diagnosis during the months of August-November in 2011-2013 compared to 2005-2007. This could be due to changes in environmental or infectious factors.
Patients from southern states were also less likely to receive a CSD diagnosis in 2011-2013 compared to 2005-2007, with a relative risk of 0.76. This could suggest regional differences in disease prevalence or reporting.
Modern Epidemiology
Cat scratch disease is a zoonotic infection caused by the gram-negative bacteria Bartonella henselae, spread through exposure to cat fleas or a cat bite or scratch.
The disease has been recorded throughout the United States, with an incidence of hospitalizations due to cat scratch disease ranging from 0.77 to 0.86 cases per 100,000 individuals in the general population.
Cat scratch disease is more common in children aged 5 to 9 years than in any other age group.
In the late 1970s and early 1980s, the incidence of hospitalizations due to cat scratch disease was 0.77 to 0.86 cases per 100,000 individuals, while by the year 2000, it had fallen to 0.60 cases per 100,000 children.
The researchers found that 12,735 cases of cat scratch disease were managed on an outpatient basis, while the remaining 538 cases required hospitalization.
Inpatient admissions related to cat scratch disease were more commonly observed in males than females in certain age groups, including those aged 0 to 4 years, 25 to 29 years, and 40 to 49 years.
The total direct medical costs associated with cat scratch disease in the United States were estimated at nearly $9.8 million annually.
Getting Infected
Getting infected with cat-scratch disease is a common occurrence, especially if you're around cats that carry the B. henselae bacterium.
Forty percent of cats carry this bacterium at some point in their lives, according to the CDC.
Cats get infected when a flea bites them or when flea "dirt" (feces) gets into a wound.
Kittens and young cats, up to six months old, are particularly likely to be carriers of the bacterium.
Visuals
Cat scratch disease incidence varies significantly across different regions in the United States. The West South Central, East South Central, and South Atlantic divisions have the highest incidence rates, with 6.1-6.4 cases per 100,000 population.
The Mountain division has the lowest incidence rate, with only 2.2 cases per 100,000 population, likely due to the lower prevalence of cat fleas in this region. This highlights the importance of considering regional differences when assessing the risk of cat scratch disease.
The South Atlantic division has the highest overall proportion of cases, accounting for 26.3% of all cases, followed closely by the West South Central division with 19.7%.
Figure 1

The data in Figure 1 reveals a significant variation in the average annual incidence of cat-scratch disease outpatient diagnoses and inpatient admissions across different regions of the United States between 2005 and 2013.
Incidence rates were highest in the West South Central, East South Central, and South Atlantic divisions, with rates ranging from 6.1 to 6.4 cases per 100,000 population.
The Mountain division had the lowest incidence rate at 2.2 cases per 100,000 population, likely due to the lower prevalence of cat fleas in this region.
The South Atlantic division accounted for the highest overall proportion of cases at 26.3%, followed closely by the West South Central division at 19.7%.
Figure 2
Let's take a closer look at Figure 2, which shows the geographic distribution of cat-scratch disease by US census division in the United States from 2005-2013.
There were less than 10 cases reported in Alaska during this time period. The same was true for Hawaii, where fewer than 10 cases were documented.
The rates of cat-scratch disease varied significantly across different regions. On average, there were 10 cases per 100,000 population per year.
Cat-scratch disease is a significant health concern in many parts of the country.
Figure 4

Figure 4 shows a clear pattern in the seasonal variation of cat scratch disease outpatient diagnoses and inpatient admissions in the United States from 2005 to 2013.
Cat scratch disease diagnoses peaked in the summer months, with July being the highest.
The number of inpatient admissions for cat scratch disease also followed a similar pattern, with a slight delay in the peak, occurring in August.
This suggests that cat scratch disease is more prevalent during the warmer months, possibly due to increased outdoor activity and exposure to infected cats.
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